Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer
نویسندگان
چکیده
منابع مشابه
Signal transduction abnormalities in cancer mitogen-activated protein kinase regulation is altered in breast cancer.
The role of cytoplasmic signal transduction pathways contributing to cell transformation and cancer is a generally accepted concept. The involvement of tyrosine kinase–encoded growth factor receptors and Ras in many cancers is unequivocal. Hyperexpression and/or mutation of the EGF receptor (erbB1) and Neu (erbB2) in combination with the establishment of autocrine/paracrine loops for their liga...
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The tumor suppressor, death-associated protein kinase (DAPK), is a Ca(2+)/calmodulin-regulated Ser/Thr kinase with an important role in regulating cytoskeletal dynamics. Autophosphorylation within the calmodulin-binding domain at Ser-308 inhibits DAPK catalytic activity. Dephosphorylation of Ser-308 by a previously unknown phosphatase enhances kinase activity and proteasome-mediated degradation...
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Endothelial cells are the interface between hemodynamic fluid flow and vascular tissue contact. They actively translate physical and chemical stimuli into intracellular signaling cascades which in turn regulate cell function, and endothelial dysfunction leads to inflammation and diseased conditions. For example, atherosclerosis, a chronic vascular disease, favorably develops in regions of distu...
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Enzymes of the eukaryotic protein kinase superfamily catalyze the reversible transfer of the gamma-phosphate from ATP to amino acid side chains of proteins. Protein kinase function can be counteracted by the action of phosphoprotein phosphatases. Phosphorylation status of a protein can have profound effects on its activity and interaction with other proteins. An estimated 1 to 3% of functional ...
متن کاملMathematical models of protein kinase signal transduction.
We have developed a mathematical theory that describes the regulation of signaling pathways as a function of a limited number of key parameters. Our analysis includes linear kinase-phosphatase cascades, as well as systems containing feedback interactions, crosstalk with other signaling pathways, and/or scaffolding and G proteins. We find that phosphatases have a more pronounced effect than kina...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2009
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2009.07414.x